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Potters Heartburn Relief Plus Mixture

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SUMMARY OF PRODUCT CHARACTERISTICS

1    NAME OF THE MEDICINAL PRODUCT

Potter’s Heartburn Relief Plus Mixture

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

Each 5 ml of oral liquid contains:-

0.99 ml of extract (as liquid extract) from Meadowsweet Herb (Filipendula ulmaria (L.) Maxim) (1:1) (equivalent to 0.99 g Meadowsweet herb)

Extraction Solvent: Water

0.374 ml of extract (as liquid extract) from Gentian Root( Gentiana lutea L.) (1.1) (equivalent to 0.04g Gentian Root)

Extraction Solvent: Water

0.2 ml of extract (as liquid extract) from Euonymus Bark (Euonymus atropurpureus Jacq.) (1:5) (equivalent to 0.04 g Euonymus bark)

Extraction Solvent: 45% Ethanol v/v

Excip    ients:

5 ml of oral liquid contains 0.65 ml ethanol and 0.99 g sucrose. (See section 4.4 ‘Special warnings and precautions for use’.)

For full list of excipients, see section 6.1

3 PHARMACEUTICAL FORM

Oral liquid.

A dark reddish brown liquid.

4    CLINICAL PARTICULARS

4.1    Therapeutic indications

A traditional herbal medicinal product used for the symptomatic relief of indigestion, heartburn and flatulence, based on traditional use only.

4.2 Posology and method of administration

For oral use only.

Adults and the elderly: Take one 5m l teaspoonful after meals three or four times a day.

Not recommended for children and adolescents under 18 years of age. (See section 4.4 ‘Special warnings and precautions for use’).

If symptoms worsen or do not improve after one week a doctor or a qualified healthcare practitioner should be consulted.

4.3 Contraindications

Hypersensitivity to the active ingredients, salicylates or any of the excipients. Peptic ulcer.

4.4 Special warnings and precautions for use

Do not exceed the stated dose.

If s ymptoms worsen or do not im prove after one week, a doctor or a qua lified healthcare practitioner should be consulted.

Not recommended for children and adolescents under 18 y ears of age because data are not sufficient and medical advice should be sought.

This medicinal product contains 13% v/v ethanol (alcohol), i.e. up to 520 mg per dose, equivalent to 13 ml beer, 5.4 ml wine per dose.

Harmful for those suffering from alcoholism. To be taken into account in pregnant or breast-feeding women, children and high-risk groups such as patients with liver disease or epilepsy.

This medicinal product contains sucrose.

Patients with rare hereditary problems of fructose intolerance, glucose-glactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.

4.5 Interaction with other medicinal products and other forms of interaction

Not to be used concomitantly with salicylates and other NSAIDs without medical advice.

Contains alcohol and should be avoided in patients taking other medicines known to interact with alcohol (e.g. metronidazole).

4.6 Fertility, pregnancy and lactation

The safety of this product during pregnancy and lactation has not been established, therefore the use of this product during pregnancy and lactation is not recommended.

Studies on fertility have not been carried out.

4.7 Effects on ability to drive and use machines

No studies on the effect on the ability to drive and use machines have been performed.

This product contains alcohol and therefore may impair ability to drive or operate machines. If affected do not drive or operate machines (See Section

4.4 ‘Special warnings and precautions for use’.)

4.8 Undesirable effects

For Gentian root, gastrointestinal disorders have been observed, tachycardia and pruritus have been reported and headache may occur. The frequency is not known.

If other adverse reactions not mentioned above occur, a doctor or a qualified healthcare practitioner should be consulted.

4.9 Overdose

No cases of overdose have been reported.

Overdose of this product may result in alcohol intoxication: the amount of alcohol in a full bottle (13 g in 100 ml; 26 g in 200 ml: equivalent to 0.4 and 0.8 large glasses of wine, respectively) may result in intoxication and should be treated accordingly.

5    PHARMACOLOGICAL PROPERTIES

5.1    Pharmacodynamic properties

Not required as per Article 16c(1)(a)(iii) of Directive 2001/83/EC as amended.

5.2 Pharmacokinetic properties

Not required as per Article 16c(1)(a)(iii) of Directive 2001/83/EC as amended.

5.3 Preclinical safety data

Adequate tests on reproductive toxicity, genotoxicity and carcinogenicity have not been performed.

For some xanthones which are among the constituents of Gentiana lutea, positive results were found in the AMES test (pre-incubation method). Assessment of preclinical safety requires further studies towards these effects.

6    PHARMACEUTICAL PARTICULARS

6.1    List of excipients

Ethanol Tragacanth Glycerol Syrup (sucrose)

Peppermint Oil Fennel Oil

Infusion of Clove, Concentrated (cloves, ethanol and water)

Sodium Bicarbonate

Water

6.2 Incompatibilities

None known.

6.3 Shelf life

3 years.

6.4 Special precautions for storage

Do not store above 25°C. Store in the original container.

6.5 Nature and contents of container

Amber glass bottle with child-resistant tamper evident EPE cap contained in cardboard carton: 90 ml, 150 ml, 200 ml or 250 ml.

Not all pack sizes may be marketed.

Special precautions for disposal

6.6


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There are no special precautions for disposal.

MARKETING AUTHORISATION HOLDER

Vifor Pharma UK Ltd 1 Botanic Court,

Martland Park,

Wigan,

WN5 0JZ,

UK.

Trading as: Potters, Wigan WN5 0JZ

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MARKETING AUTHORISATION NUMBER(S)

THR 33656/0060

DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION

05/04/2013

DATE OF REVISION OF THE TEXT


05/04/2013