Patient Information Leaflet

If you forget to take this product:

Continue to take your usual dose at the usual time, it does not matter if you have missed a dose.

After taking this product:

You must speak to a doctor or qualified healthcare practitioner if your symptoms worsen, if they do not improve after six weeks, or if any of the side effects become serious or if you notice any side effects not mentioned in the leaflet.

If you have any questions, or are unsure about anything, please ask your doctor, pharmacist or qualified healthcare practitioner.

Also sunburn-like reactions on skin exposed to strong sunlight or strong ultra-violet (UV) irradiation e.g. solarium have been reported, particularly in fair skinned individuals. Other side effects that have been reported include headaches, nerve pain or tingling, anxiety, dizziness and mania.

If any of the above side effects become serious or if you experience any side effects not listed, consult your doctor or qualified healthcare practitioner.

5. How to store this product

6. Further information

4. Possible side effects

Like all medicines, this product

can have side effects.

The following side effects have

been reported:

•    Gastrointestinal disorders such as indigestion, loss of appetite, nausea, diarrhoea and constipation.

•    Fatigue and restlessness.

•    Allergic skin reactions such as rash, hives or itching of the skin. If you experience allergic skin reactions, stop taking the product and consult your doctor.

5

Do not store above 25°C. Store in the original package Keep the tablets out of the reach and sight of children. Keep your tablets in the blister pack until it is time to take them.

Do not use Thompson & Capper St John’s Wort tablets after the expiry date which is stated on the box and blister pack. The expiry date refers to the last day of that month. Return any out of date tablets to your pharmacist who will dispose of them for you.

Each film-coated tablet contains 425mg of extract (as dry extract) from St John’s Wort aerial parts {Hypericum perforatum L.) (5-7/1) (equivalent to 2125mg-2975mg of St John’s Wort). Extraction solvent: Ethanol 60% V/V.

This product also contains the following ingredients:

Excipients in the extract: Maltodextrin, silica colloidal anhydrous.

Tablet core: Maltodextrin, microcrystalline cellulose, croscarmellose sodium, stearic acid, magnesium stearate, silica colloidal anhydrous.

Tablet coating: Hypromellose, iron oxide red (E172), titanium dioxide (E171), glycerol.

The tablets are red coated and oval shaped.

Each pack contains 30, 60 or 90 coated tablets Not all pack sizes may be marketed.

Traditional registration holder and manufacturer for this product: Thompson & Capper Ltd. Hardwick Road, Astmoor, Runcorn, Cheshire. WA7 1 PH. UK

THR 01359/0005 You can help make medicines safer by reporting any side effects to the Yellow Card Scheme at

www.yellowcard.gov.uk. Alternatively you can get a paper Yellow Card from your GP’s surgery or call freephone 0808 100 3352 (available 10am - 2pm Monday - Friday).

If you would like further information about this product or a version of this leaflet in large print or audio format please contact:

Telephone:

01928 573734 Email: Enquiries@ tablets2buy.com This leaflet was revised in June 2011

6

THOMPSON & CAPPER

ST JOHN'SWORT tablets

STJOHN’S WORT EXTRACT 425mg

Please read this information carefully before you start taking these tablets. It contains some important information about this product. Keep this leaflet with the tablets. You may want to read it again or show it to your doctor, pharmacist or qualified healthcare practitioner.

You must speak to a qualified healthcare practitioner if your symptoms worsen, if they do not improve after six weeks, or if side effects not mentioned in this leaflet occur.

What is in this leaflet

This product is a traditional herbal medicinal product containing St John’s Wort extract.

Thompson & Capper St John’s Wort tablets are a traditional herbal medicinal product used to relieve the symptoms of slightly low mood and mild anxiety based on traditional use only.

1

2. Before you take this product

2.1 Do not take this product if:

•    your skin is exceptionally sensitive to sunlight (photosensitive)

•    you are having light treatment (phototherapy) for any condition

•    you are suffering from depression (see below)

•    you are pregnant or breastfeeding

•    you are allergic to any of the ingredients (see section 6)

•    Are under the age of 18 years.

Suffering from depression?

Symptoms of depression include feelings of helplessness and hopelessness, loss of interest in daily activities, appetite or weight changes, changes in sleep pattern, loss of energy and difficulty concentrating. If your doctor has told you that you are suffering from depression do not use this product. If you think that you may be suffering from depression you should tell your doctor before taking this product.

While you are taking this product:

•    avoid excessive sunbathing or the use of sunbeds/ solariums

•    stop using it at least 10 days prior to undergoing any surgery.

2.2    Driving and operating machinery

In rare cases St John’s Wort may make you feel dizzy or sleepy. If affected do not drive or use machines.

2.3    Taking this product with other medicines

St John’s Wort can affect the way some medicines work and reduce their effectiveness. Medicines that can be affected by St John’s Wort include prescription medicines, and those that you may have bought without a prescription. Therefore it is important that you do not take Thompson & Capper St John’s Wort if you are using any of the medicines listed.

All hormonal contraceptives:

The birth control ‘Pill’, emergency contraception, hormonal implants, creams, patches, intra-uterine devices with hormones.

All medicines for depression/ anxiety: Amitriptyline, clomipramine, moclobemide, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, duloxetine, venlafaxine.

All hormonal replacement therapy (HRT) treatments: HRT tablets, patches, gels, vaginal rings.

All medicines for thinning the blood (anticoagulants):

Warfarin, acenocoumarol.

All medicines for epilepsy: Carbamazepine, phenobarbitone, phenytoin, primidone, sodium valproate.

All immunosuppressant medicines: Ciclosporin, tacrolimus.

All medicines for HIV infections: Amprenavir, atazanavir, darunavir, fosamprenavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, tipranavir, efavirenz, nevirapine, delavirdine.

Some medicines for cholesterol: Simvastatin, atorvastatin.

Some medicines for cancer:

Irinotecan, dasatinib, erlotinib, imatinib, sorafenib, sunitinib, etoposide, mitotane.

Some medicines for heart disease: Digoxin, ivabradine, amiodarone.

Some medicines for migraines: Almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan.

Some medicines for high blood pressure: Amlodipine, nifedipine, felodipine, verapamil.

A medicine for regulating mood: Lithium.

A thyroid hormone: Thyroxine.

2.3 Taking this product with other medicines (CONTINUED)

Thompson & Capper St John’s Wort may also affect the following medicines. Therefore do not take this product with these medicines unless a doctor has said it is safe to do so:

•    fentanyl, propofol, sevoflurane, and midazolam

(anaesthetics/pre-operative

medicines)

•    tramadol (an analgesic)

•    erythromycin, clarithromycin and telithromycin (antibiotics)

•    itraconazole and voriconazole (antifungals)

•    artemether and lumefantrine (antimalarials)

•    rasagiline (an anti-Parkinson’s medicine)

•    aripiprazole (an

antipsychotic medicine)

•    buspirone (an anxiolytic)

•    aprepitant (used to treat post-operative vomiting)

•    butobarbital and phenobarbital (barbiturates)

•    methyl phenidate (a central nervous system or CNS

stimulant)

•    exemestane (a hormone antagonist)

•    eplerenone (a diuretic)

•    lansoprazole and omeprazole (proton pump inhibitors)

•    theophylline

(a bronchodilator)

•    gliclazide (an antidiabetic medicine).

3. How to take this product

Adults and the elderly

Take 1 tablet daily. Swallow the tablet whole with some water or other liquid. Do not chew the tablet.

Do not exceed the stated dose.

If you take too much of this product (overdose):

If you take more than the recommended dose, speak to a doctor, pharmacist or qualified healthcare practitioner and take this leaflet with you.

2

3

4